Few brain imaging studies of schizophrenia involve samples with enhanced genetic homogeneity. We compared MRI volumetric data between individuals with 1q21-q23 linked familial schizophrenia associated with NOS1AP and their first and second degree unaffected relatives. We found significant gray matter reductions in the anterior cingulate gyrus in both affected individuals and their unaffected first degree relatives when compared with their unaffected second degree relatives. These results suggest that the changes are primarily due to genetic risk and not illness effects, and may represent an intermediate phenotype.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2025.
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#8,534,976
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Outputs from Schizophrenia Research
#2,189
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of 105,214 outputs
Outputs of similar age from Schizophrenia Research
#12
of 27 outputs
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