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Attention Score in Context
| Title |
Effects of Different Dietary Protocols on General Activity and Frailty of Male Wistar Rats During Aging
|
|---|---|
| Published in |
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, February 2018
|
| DOI | 10.1093/gerona/gly015 |
| Pubmed ID | |
| Authors |
Smilja T Todorovic, Kosara R Smiljanic, Sabera D Ruzdijic, Aleksandra N Mladenovic Djordjevic, Selma D Kanazir |
| Abstract |
Dietary restriction (DR) is an important experimental paradigm for lifespan and healthspan extension, but its specific contribution regarding the type, onset and duration are still debatable. This study was designed to examine the impact of different dietary protocols by assessing the behavioral changes during aging. We exposed male Wistar rats of various age to ad libitum (AL) or DR (60% of AL daily intake) feeding regimens with different onsets. The impact of DR on locomotor activity, memory and learning was examined in 12-, 18- and 24-month-old treated animals and controls using open field (OF) and Y maze tests. We have also evaluated the effects of different DR's through the quantification of animal frailty, using behavioral data to create the frailty score (FS). Our results indicated that dietary restriction improves general animal activity, spatial memory and decreases frailty with the effect being highly dependent on DR duration and onset. Notably, life-long restriction started at young age had the most profound effect. In contrast, shorter duration and later onset of restricted diet had significantly lower or no impact on animal's behavior and frailty. This study signifies the importance of DR starting point and duration as critical determinants of DR effects on healthspan. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 17% |
| Student > Doctoral Student | 5 | 17% |
| Student > Bachelor | 4 | 13% |
| Student > Master | 2 | 7% |
| Researcher | 2 | 7% |
| Other | 5 | 17% |
| Unknown | 7 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 27% |
| Nursing and Health Professions | 4 | 13% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Neuroscience | 2 | 7% |
| Arts and Humanities | 1 | 3% |
| Other | 5 | 17% |
| Unknown | 8 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2018.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from Journals of Gerontology Series A: Biological Sciences & Medical Sciences
#3,258
of 3,967 outputs
Outputs of similar age
#282,985
of 447,410 outputs
Outputs of similar age from Journals of Gerontology Series A: Biological Sciences & Medical Sciences
#59
of 72 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,967 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.2. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 447,410 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.