The Water Drinking Test (WDT) is currently used to temporarily elevate intraocular pressure (IOP) and predict peak IOP in glaucoma. This study investigates neurovascular changes associated with WDT in normal subjects.
The effect of WDT (1 liter in 5▒min) on IOP, mean brachial blood pressure (MAP), heart rate (HR), and pattern electroretinogram (PERG) was assessed within the next hour in 16 healthy subjects (mean age 33.5±7.9▒y). As a control, testing was repeated in the same subjects without WDT one week later.
Compared to control, WDT resulted in significant peak changes of the following parameters compared to baseline: IOP: +1.7±1.8▒mm Hg after 30', MAP: +3.9±6.3▒mm Hg after 15'; HR: -9.2±9.8▒bpm after 15', PERG latency: +2.1±0.9▒ms after 15'.
In addition to IOP elevation, WDT was associated with significant changes of hemodynamic parameters and retinal ganglion cell function in young healthy subjects. As these represent risk factors for glaucoma, their assessment upon WDT might increase its predictive power for glaucoma development.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2018.
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#20,663,600
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#2,284
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Outputs of similar age from Journal of Glaucoma
#8
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