Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver

Overview of attention for article published in Journal of Biological Chemistry, February 2018

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How to prevent mTORC activation during amino acid stress https://t.co/Hw8eNIyxBk https://t.co/XfpXhWUZbP

RT @apoptosislab: Does this mean that GCN2 / phospho-eIF2alpha responds to sudden amino acid loss within minutes? (at least in the liver).…

RT @Brunorm84: Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver…

Does this mean that GCN2 / phospho-eIF2alpha responds to sudden amino acid loss within minutes? (at least in the liver). I thought that mTOR researchers had discarded GCN2 as a meaningful amino acid sensor upstream of mTOR. As usual, more complicated th…

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