| Title |
The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila
|
|---|---|
| Published in |
Cell, November 1998
|
| DOI | 10.1016/s0092-8674(00)81638-4 |
| Pubmed ID | |
| Authors |
Ralf Stanewsky, Maki Kaneko, Patrick Emery, Bonnie Beretta, Karen Wager-Smith, Steve A Kay, Michael Rosbash, Jeffrey C Hall |
| Abstract |
A new rhythm mutation was isolated based on its elimination of per-controlled luciferase cycling. Levels of period or timeless clock gene products in the mutant are flat in daily light-dark cycles or constant darkness (although PER and TIM oscillate normally in temperature cycles). Consistent with the fact that light normally suppresses TIM, cryb is an apparent null mutation in a gene encoding Drosophila's version of the blue light receptor cryptochrome. Behaviorally, cryb exhibits poor synchronization to light-dark cycles in genetic backgrounds that cause external blindness or demand several hours of daily rhythm resets, and it shows no response to brief light pulses. cryb flies are rhythmic in constant darkness, correlating with robust PER and TIM cycling in certain pacemaker neurons. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 16% |
| Japan | 3 | 16% |
| Mexico | 2 | 11% |
| Netherlands | 1 | 5% |
| Unknown | 10 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 79% |
| Scientists | 4 | 21% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 3% |
| Japan | 3 | <1% |
| United Kingdom | 3 | <1% |
| Spain | 2 | <1% |
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Czechia | 1 | <1% |
| China | 1 | <1% |
| Unknown | 366 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 104 | 27% |
| Researcher | 58 | 15% |
| Student > Bachelor | 43 | 11% |
| Student > Master | 34 | 9% |
| Professor > Associate Professor | 26 | 7% |
| Other | 51 | 13% |
| Unknown | 72 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 145 | 37% |
| Biochemistry, Genetics and Molecular Biology | 71 | 18% |
| Neuroscience | 39 | 10% |
| Chemistry | 15 | 4% |
| Medicine and Dentistry | 15 | 4% |
| Other | 24 | 6% |
| Unknown | 79 | 20% |