The safety and efficacy of pharmacologic and cellular transplantation strategies are currently being evaluated in people with spinal cord injury. In studies of people with chronic spinal cord injuries, it is thought that functional recovery will be best achieved when drug or cell therapies are combined with rehabilitation protocols. However, any functional recovery due to the therapy may be confounded by the conditioned state of the body and by training-induced effects on neuroplasticity. For this reason, we sought to investigate the effects of a multi-modal training program on several body systems. The training program included body weight supported treadmill training for locomotion, circuit resistance training for upper body conditioning, functional electrical stimulation for activation of sublesional muscles, and wheelchair skills training for overall mobility. Eight participants with chronic, thoracic-level, motor-complete spinal cord injury completed the 12 week program. After 12 weeks, upper extremity muscular strength improved significantly for all participants, and some participants experienced improvements in function which may be explained by increased strength. Neurological function did not change. Changes in pain and spasticity were highly variable between participants. This is the first demonstration of the effect of this combination of four training modalities. However, balancing participant and study-site burden with capturing meaningful outcome measures is also an important consideration.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2018.
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#24,695,554
of 30,029,034 outputs
Outputs from Journal of Neurotrauma
#2,633
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Outputs of similar age
#359,205
of 460,614 outputs
Outputs of similar age from Journal of Neurotrauma
#35
of 45 outputs
Altmetric has tracked 30,029,034 research outputs across all sources so far. This one is in the 9th percentile – i.e., 9% of other outputs scored the same or lower than it.
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