Recent work to develop and profile clinically relevant small molecule inhibitors of the spliceosome, or spliceosome-targeted therapies, have emphasized the importance of understanding the consequence of global RNA mis-splicing. @NatureMedicine https://t…
Beautiful, especially MoA studies into why splice factor modulation is selectively lethal to SF3b-mutant cells. https://t.co/mnyU4tJJJv
RT @NatureMedicine: The small molecule H3B-8800 selectively modulates RNA splicing to preferentially kill tumor cells bearing mutations in…
RT @FAndreMD: Splicing modulators are coming in oncology. I look forward to see clinical data in SF3B1 mutated cancers. @h3biomedicine htt…