Here we report that assemblies of nucleopeptides selectively sequestrate ATP in complex conditions (e.g., serum and cytosol). We develop assemblies of nucleopeptides that selectively sequester ATP over ADP. Counteracting enzymes interconvert ATP and ADP to modulate the nanostructures formed by the nucleopeptides and the nucleotides. The nucleopeptides, sequestering ATP effectively in cells, slow down efflux pumps in multidrug resistance cancer cells, thus boosting the efficacy of an anticancer drug. Examining additional 11 nucleopeptides (including D- and L-enantiomers) yields five more nucleopeptides that differentiate ATP and ADP via either precipitation or gelation. As the first example of using assemblies of nucleopeptides for interacting with ATP and disrupting intracellular ATP dynamics, this work illustrates the use of supramolecular assemblies to interact with small and essential biological molecules for controlling cell behaviors.
Pharmacology, Toxicology and Pharmaceutical Science
1
3%
Computer Science
1
3%
Other
2
5%
Unknown
13
34%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2023.
All research outputs
#10,192,248
of 34,411,289 outputs
Outputs from Angewandte Chemie. International Edition
#27,542
of 61,754 outputs
Outputs of similar age
#126,183
of 375,029 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#377
of 833 outputs
Altmetric has tracked 34,411,289 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 61,754 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 375,029 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 833 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
