| Title |
Bone and blood interactions in human health and disease
|
|---|---|
| Published in |
BONE, February 2018
|
| DOI | 10.1016/j.bone.2018.02.019 |
| Pubmed ID | |
| Authors | |
| Abstract |
Under physiologic conditions hematopoiesis takes place in the bone marrow, and the skeleton provides the structural and supportive network necessary for normal hematopoiesis. Chronic disorders affecting hematopoiesis such as sickle cell anemia and thalassemia demonstrate striking skeletal phenotypes including bone loss and increased fracture risk. There is mounting evidence that anemia in older populations may also be associated with bone fragility. Given the interconnectedness of bone and hematopoietic cells, it is important to review the potential clinical implications and opportunities for therapeutic intervention. There are recognized associations between blood-borne and solid tissue malignancy and skeletal health, but our review will focus on non-malignant disease. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 17% |
| United Kingdom | 1 | 17% |
| United States | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
| Scientists | 1 | 17% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 14% |
| Researcher | 6 | 12% |
| Student > Ph. D. Student | 4 | 8% |
| Lecturer | 3 | 6% |
| Student > Bachelor | 3 | 6% |
| Other | 9 | 18% |
| Unknown | 17 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 22% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Chemistry | 3 | 6% |
| Nursing and Health Professions | 2 | 4% |
| Immunology and Microbiology | 2 | 4% |
| Other | 7 | 14% |
| Unknown | 19 | 39% |