Title |
Effects of Statin Intensity on Clinical Outcome in Acute Myocardial Infarction Patients
|
---|---|
Published in |
Circulation Journal, February 2018
|
DOI | 10.1253/circj.cj-17-1221 |
Pubmed ID | |
Authors |
Doyeon Hwang, Hyun Kuk Kim, Joo Myung Lee, Ki Hong Choi, Jihoon Kim, Tae-Min Rhee, Jonghanne Park, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Bon-Kwon Koo, Young Jo Kim, Shung Chull Chae, Myeong Chan Cho, Chong Jin Kim, Hyeon-Cheol Gwon, Myung Ho Jeong, Hyo-Soo Kim, The KAMIR Investigators |
Abstract |
There has been debate regarding the added benefit of high-intensity statins compared with low-moderate-intensity statins, especially in patients with acute myocardial infarction (AMI).Methods and Results:The Korea Acute Myocardial Infarction Registry-National Institutes of Health consecutively enrolled 13,104 AMI patients. Of these, a total of 12,182 patients, who completed 1-year follow-up, were included in this study, and all patients were classified into 3 groups (no statin; low-moderate-intensity statin; and high-intensity statin). The primary outcome was major adverse cardiac event (MACE) including cardiac death, non-fatal MI, and repeat revascularization at 1 year. Both low-moderate-intensity and high-intensity statin significantly reduced low-density lipoprotein cholesterol (LDL-C; all P<0.001). Compared with the no statin group, both statin groups had significantly lower risk of MACE (low-moderate intensity: HR, 0.506; 95% CI: 0.413-0.619, P<0.001; high intensity: HR, 0.464; 95% CI: 0.352-0.611, P<0.001). The risk of MACE, however, was similar between the low-moderate- and high-intensity statin groups (HR, 0.917; 95% CI: 0.760-1.107, P=0.368). Multivariable adjustment, propensity score matching, and inverse probability weighted analysis also produced the same results. When adequate LDL-C level is achieved, patients on a low-moderate-intensity statin dose have similar cardiovascular outcomes to those on high-intensity statins. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 19% |
Other | 3 | 14% |
Professor > Associate Professor | 3 | 14% |
Researcher | 2 | 10% |
Student > Doctoral Student | 1 | 5% |
Other | 1 | 5% |
Unknown | 7 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 38% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 10% |
Computer Science | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Unknown | 9 | 43% |