It is uncertain whether antiphospholipid antibodies (APA) increase the risk of recurrence after a first unprovoked venous thromboembolism (VTE). We tested for anticardiolipin antibodies, anti-β2 glycoprotein I antibodies and lupus anticoagulant on two occasions about six months apart in 307 patients with a first unprovoked VTE who were part of a prospective cohort study. We then determined if APA were associated with recurrent thrombosis in the 290 patients who stopped anticoagulant therapy in response to negative D-dimer results.Compared with those without an APA, the hazard ratios for recurrent VTE were 1.8 (95% confidence interval 0.9 to 3.7; p=0.09) in the 25.9% of patients with an APA on one or more occasion, 2.7 (95%CI 1.1 to 6.7; p=0.03) in the 9.0% of patients with the same APA on two occasions, and 4.5 (95%CI 1.5 to 13.0; p=0.006) in the 3.8% of patients with two or three different APA types on either the same or different occasions. There was no association between having an APA and D-dimer levels. We conclude that having the same type of APA on two occasions, or having more than one type of APA on the same or different occasions, is associated with recurrent thrombosis in patients with a first unprovoked VTE who stop anticoagulant therapy in response to negative D-dimer tests. APA and D-dimer levels appear to be independent predictors of recurrence in patients with unprovoked VTE.
Pharmacology, Toxicology and Pharmaceutical Science
1
1%
Other
4
5%
Unknown
31
42%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2019.
All research outputs
#1,498,700
of 34,245,361 outputs
Outputs from Blood
#1,402
of 46,765 outputs
Outputs of similar age
#25,248
of 372,631 outputs
Outputs of similar age from Blood
#23
of 232 outputs
Altmetric has tracked 34,245,361 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,765 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 372,631 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 232 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.
