A pre-existing rare PIK3CAE545K subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling

Overview of attention for article published in Cancer Discovery, April 2018

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a new mutant explains resistance to CDK4/6 inhibitors https://t.co/fkiYg68HPI

RT @NatRevClinOncol: Data support targeting of mTORC1/2 to overcome MEKi plus CDK4/6i resistance mediated by PI3K pathway/S6 kinase signall…

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