| Title |
The ADF/cofilin family: actin-remodeling proteins
|
|---|---|
| Published in |
Genome Biology, April 2002
|
| DOI | 10.1186/gb-2002-3-5-reviews3007 |
| Pubmed ID | |
| Authors |
Sutherland K Maciver, Patrick J Hussey |
| Abstract |
The ADF/cofilins are a family of actin-binding proteins expressed in all eukaryotic cells so far examined. Members of this family remodel the actin cytoskeleton, for example during cytokinesis, when the actin-rich contractile ring shrinks as it contracts through the interaction of ADF/cofilins with both monomeric and filamentous actin. The depolymerizing activity is twofold: ADF/cofilins sever actin filaments and also increase the rate at which monomers leave the filament's pointed end. The three-dimensional structure of ADF/cofilins is similar to a fold in members of the gelsolin family of actin-binding proteins in which this fold is typically repeated three or six times; although both families bind polyphosphoinositide lipids and actin in a pH-dependent manner, they share no obvious sequence similarity. Plants and animals have multiple ADF/cofilin genes, belonging in vertebrates to two types, ADF and cofilins. Other eukaryotes (such as yeast, Acanthamoeba and slime moulds) have a single ADF/cofilin gene. Phylogenetic analysis of the ADF/cofilins reveals that, with few exceptions, their relationships reflect conventional views of the relationships between the major groups of organisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Germany | 2 | 1% |
| United Kingdom | 2 | 1% |
| Portugal | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 174 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 23% |
| Researcher | 34 | 18% |
| Student > Master | 24 | 13% |
| Student > Bachelor | 19 | 10% |
| Student > Doctoral Student | 13 | 7% |
| Other | 26 | 14% |
| Unknown | 26 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 74 | 40% |
| Biochemistry, Genetics and Molecular Biology | 42 | 23% |
| Medicine and Dentistry | 11 | 6% |
| Neuroscience | 9 | 5% |
| Chemistry | 5 | 3% |
| Other | 15 | 8% |
| Unknown | 28 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2009.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Genome Biology
#3,489
of 4,467 outputs
Outputs of similar age
#42,910
of 127,454 outputs
Outputs of similar age from Genome Biology
#7
of 20 outputs
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