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The Synthesis and preliminary pharmacological evaluation of 4-Methyl fentanyl

Overview of attention for article published in Bioorganic & Medicinal Chemistry Letters, September 2000
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

patent
3 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
32 Dimensions

Readers on

mendeley
33 Mendeley
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Title
The Synthesis and preliminary pharmacological evaluation of 4-Methyl fentanyl
Published in
Bioorganic & Medicinal Chemistry Letters, September 2000
DOI 10.1016/s0960-894x(00)00394-2
Pubmed ID
Authors

Ivan V. Mićović, Milovan D. Ivanović, Sonja M. Vuckovic, Milica Š. Prostran, Ljiljana Došen-Mićović, Vesna D. Kiricojević

Abstract

The synthesis of 4-methyl fentanyl, a prototype of a novel class of fentanyl analogues has been effected in 5 steps, starting from N-ethoxycarbonyl-4-piperidone (approximately 20% overall yield). In the key step, N-phenylation of secondary aliphatic amide intermediare was achieved by a novel reaction, using diphenyliodonium chloride for the phenyl group transfer. Preliminary pharmacological results indicate that 4-methyl fentanyl is a super potent narcotic analgesic, about four times more potent than fentanyl.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 27%
Researcher 8 24%
Student > Ph. D. Student 3 9%
Student > Postgraduate 2 6%
Student > Master 2 6%
Other 3 9%
Unknown 6 18%
Readers by discipline Count As %
Chemistry 19 58%
Agricultural and Biological Sciences 2 6%
Medicine and Dentistry 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Physics and Astronomy 1 3%
Other 4 12%
Unknown 4 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2018.
All research outputs
#5,447,195
of 25,374,917 outputs
Outputs from Bioorganic & Medicinal Chemistry Letters
#2,453
of 13,778 outputs
Outputs of similar age
#6,308
of 37,744 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry Letters
#20
of 103 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,778 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 37,744 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.