Using serum biotin concentration as the indicator, a previous study reported biotin deficiency resulting from long-term anticonvulsant therapy. However, serum biotin may not be a good indicator of tissue biotin status. Using better indicators of biotin status in anticonvulsant-treated subjects, we found increased urinary excretion of biotin catabolites and 3-hydroxyisovaleric acid, an organic acid produced in greater quantities secondary to reduced activity of a biotin-dependent carboxylase. We conclude that anticonvulsant treatment led to increased biotin catabolism and probably to reduced biotin status.
Pharmacology, Toxicology and Pharmaceutical Science
3
20%
Agricultural and Biological Sciences
2
13%
Chemical Engineering
1
7%
Chemistry
1
7%
Other
0
0%
Unknown
4
27%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2006.
All research outputs
#5,726,524
of 26,316,852 outputs
Outputs from Neurology
#8,632
of 21,128 outputs
Outputs of similar age
#4,191
of 29,223 outputs
Outputs of similar age from Neurology
#5
of 47 outputs
Altmetric has tracked 26,316,852 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 21,128 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.3. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 29,223 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.
