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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients
|
|---|---|
| Published in |
Journal of Neuroimmunology, March 2018
|
| DOI | 10.1016/j.jneuroim.2018.03.001 |
| Pubmed ID | |
| Authors |
Verica Paunovic, Irena Vukovic Petrovic, Marina Milenkovic, Kristina Janjetovic, Vera Pravica, Irena Dujmovic, Emina Milosevic, Vanja Martinovic, Sarlota Mesaros, Jelena Drulovic, Vladimir Trajkovic |
| Abstract |
Autophagy, a process of controlled self-digestion which regulates cell homeostasis, is involved in innate and adaptive immunity. We investigated the expression of autophagy genes and autophagic activity in distinct lymphocyte populations in treatment-naive MS patients. The mRNA and protein levels of autophagy-related (ATG)5, required for autophagosome formation, were increased in CD4+and CD4-T cells, but not B cells of MS patients compared to control subjects. The expression of other investigated autophagy genes, as well as the autophagic activity, did not significantly differ between the two groups. ATG5 mRNA levels in CD4+T cells from MS patients were positively correlated with those of the proinflammatory cytokine tumor necrosis factor. These data suggest that autophagy-independent increase in ATG5 expression might be associated with the proinflammatory capacity of T cells in multiple sclerosis. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 22% |
| Student > Ph. D. Student | 5 | 14% |
| Student > Bachelor | 5 | 14% |
| Professor | 3 | 8% |
| Student > Postgraduate | 3 | 8% |
| Other | 6 | 16% |
| Unknown | 7 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 10 | 27% |
| Neuroscience | 7 | 19% |
| Biochemistry, Genetics and Molecular Biology | 5 | 14% |
| Medicine and Dentistry | 3 | 8% |
| Agricultural and Biological Sciences | 1 | 3% |
| Other | 4 | 11% |
| Unknown | 7 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2018.
All research outputs
#20,663,600
of 25,382,440 outputs
Outputs from Journal of Neuroimmunology
#2,445
of 3,012 outputs
Outputs of similar age
#271,251
of 347,366 outputs
Outputs of similar age from Journal of Neuroimmunology
#20
of 31 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,012 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 347,366 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.