Title |
Association of Pentraxin-3, Galectin-3 and Matrix Metalloproteinase-9/Timp-1 with Cardiovascular Risk in Renal Disease Patients.
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Published in |
Acta clinica Croatica, January 2017
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DOI | 10.20471/acc.2017.56.04.14 |
Pubmed ID | |
Authors |
Milica Miljković, Aleksandra Stefanović, Nataša Bogavac-Stanojević, Sanja Simić-Ogrizović, Jerka Dumić, Darko Černe, Zorana Jelić-Ivanović, Jelena Kotur-Stevuljević |
Abstract |
Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre-dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin-3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p<0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre-dialysis patients and controls (p<0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p<0.01 and p<0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients with high and low risk of a coronary event. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 16% |
Student > Bachelor | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Student > Doctoral Student | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Other | 5 | 20% |
Unknown | 6 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 20% |
Medicine and Dentistry | 5 | 20% |
Chemistry | 2 | 8% |
Psychology | 2 | 8% |
Nursing and Health Professions | 1 | 4% |
Other | 2 | 8% |
Unknown | 8 | 32% |