| Title |
Genetic determinants of statin intolerance
|
|---|---|
| Published in |
Lipids in Health and Disease, March 2007
|
| DOI | 10.1186/1476-511x-6-7 |
| Pubmed ID | |
| Authors |
Jisun Oh, Matthew R Ban, Brooke A Miskie, Rebecca L Pollex, Robert A Hegele |
| Abstract |
Statin-related skeletal muscle disorders range from benign myalgias--such as non-specific muscle aches or joint pains without elevated serum creatinine kinase (CK) concentration--to true myositis with >10-fold elevation of serum CK, to rhabdomyolysis and myoglobinuria. The genetic basis of statin-related muscle disorders is largely unknown. Because mutations in the COQ2 gene are associated with severe inherited myopathy, we hypothesized that common, mild genetic variation in COQ2 would be associated with inter-individual variation in statin intolerance. We studied 133 subjects who developed myopathy on statin monotherapy and 158 matched controls who tolerated statins without incident or complaint. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 2% |
| United States | 1 | 1% |
| Australia | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 90 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 18 | 19% |
| Student > Ph. D. Student | 16 | 17% |
| Researcher | 13 | 14% |
| Other | 10 | 11% |
| Student > Master | 8 | 8% |
| Other | 24 | 25% |
| Unknown | 6 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 43% |
| Agricultural and Biological Sciences | 17 | 18% |
| Biochemistry, Genetics and Molecular Biology | 10 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
| Nursing and Health Professions | 3 | 3% |
| Other | 8 | 8% |
| Unknown | 9 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2021.
All research outputs
#6,461,879
of 23,342,092 outputs
Outputs from Lipids in Health and Disease
#393
of 1,477 outputs
Outputs of similar age
#24,515
of 77,728 outputs
Outputs of similar age from Lipids in Health and Disease
#1
of 2 outputs
Altmetric has tracked 23,342,092 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,477 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 77,728 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them