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Mendeley demographics
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| Title |
Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid
|
|---|---|
| Published in |
Experientia, January 1996
|
| DOI | 10.1007/bf01922423 |
| Pubmed ID | |
| Authors | |
| Abstract |
A polyenoic fatty-acid isomerase (PFI) from a red marine alga was used to convert anandamide (5Z,8Z,11Z,14Z-eicosatetraenoyl-N-ethan olamide) to the 5Z,7E,9E,14Z-eicosatetraenoyl-N-ethanol amide isomer. This novel eicosanoid, termed conjugated triene anandamide (CTA), was assessed for its ability to bind to the cannabinoid receptor in rat brain membrane preparations. CTA is a high affinity cannabimimetic substance whose novel structure provides new insight into structure-activity relationships of cannabinoid receptor ligands. These experiments illustrate the utility of enzymes isolated from marine organisms in the development of pharmacological probes. |
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Mendeley demographics
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 7% |
| Unknown | 13 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 29% |
| Student > Bachelor | 2 | 14% |
| Professor | 2 | 14% |
| Student > Ph. D. Student | 2 | 14% |
| Lecturer > Senior Lecturer | 1 | 7% |
| Other | 2 | 14% |
| Unknown | 1 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 29% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 21% |
| Agricultural and Biological Sciences | 3 | 21% |
| Social Sciences | 2 | 14% |
| Engineering | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 1 | 7% |