Title |
Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity
|
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Published in |
Steroids, December 1996
|
DOI | 10.1016/s0039-128x(96)00203-6 |
Pubmed ID | |
Authors |
Nina M. Todorović, Milutin Stefanovic, Bernard Tinant, Jean-Paul Declercq, Michael T. Makler, Bogdan A. S̆olaja |
Abstract |
Cholestane-derived gem-dihydroperoxides and tetraoxanes were synthesized starting from 5 alpha- and 5 beta-cholestan-3-ones by acid-catalyzed addition of hydrogen peroxide to the ketone. They were characterized by IR, NMR, and mass spectroscopy analysis aided by molecular mechanics calculations, and, in the instance of 5 beta-cholestane-3 alpha,3 beta-dihydroperoxide (6), by x-ray analysis. The synthesized compounds were tested in vitro against Plasmodium falciparum Sierra Leone (D6) and Indochina (W2) malaria clones. All compounds were inactive to both clones, with the exception of tetraoxane 7a, which exhibited modest activity toward D6 clone with IC50 = 155 nM. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | 6% |
Unknown | 16 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 29% |
Student > Ph. D. Student | 2 | 12% |
Other | 2 | 12% |
Researcher | 2 | 12% |
Professor > Associate Professor | 1 | 6% |
Other | 0 | 0% |
Unknown | 5 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 8 | 47% |
Agricultural and Biological Sciences | 2 | 12% |
Economics, Econometrics and Finance | 1 | 6% |
Medicine and Dentistry | 1 | 6% |
Unknown | 5 | 29% |