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Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity

Overview of attention for article published in Steroids, December 1996
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

patent
2 patents

Readers on

mendeley
17 Mendeley
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Title
Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity
Published in
Steroids, December 1996
DOI 10.1016/s0039-128x(96)00203-6
Pubmed ID
Authors

Nina M. Todorović, Milutin Stefanovic, Bernard Tinant, Jean-Paul Declercq, Michael T. Makler, Bogdan A. S̆olaja

Abstract

Cholestane-derived gem-dihydroperoxides and tetraoxanes were synthesized starting from 5 alpha- and 5 beta-cholestan-3-ones by acid-catalyzed addition of hydrogen peroxide to the ketone. They were characterized by IR, NMR, and mass spectroscopy analysis aided by molecular mechanics calculations, and, in the instance of 5 beta-cholestane-3 alpha,3 beta-dihydroperoxide (6), by x-ray analysis. The synthesized compounds were tested in vitro against Plasmodium falciparum Sierra Leone (D6) and Indochina (W2) malaria clones. All compounds were inactive to both clones, with the exception of tetraoxane 7a, which exhibited modest activity toward D6 clone with IC50 = 155 nM.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 29%
Student > Ph. D. Student 2 12%
Other 2 12%
Researcher 2 12%
Professor > Associate Professor 1 6%
Other 0 0%
Unknown 5 29%
Readers by discipline Count As %
Chemistry 8 47%
Agricultural and Biological Sciences 2 12%
Economics, Econometrics and Finance 1 6%
Medicine and Dentistry 1 6%
Unknown 5 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2016.
All research outputs
#5,447,195
of 25,374,917 outputs
Outputs from Steroids
#210
of 1,807 outputs
Outputs of similar age
#8,433
of 92,559 outputs
Outputs of similar age from Steroids
#5
of 19 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,807 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,559 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.