You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Acid–base equilibria and solubility of loratadine and desloratadine in water and micellar media
|
|---|---|
| Published in |
Journal of Pharmaceutical & Biomedical Analysis, October 2008
|
| DOI | 10.1016/j.jpba.2008.09.043 |
| Pubmed ID | |
| Authors |
Gordana Popović, Mira Čakar, Danica Agbaba |
| Abstract |
Acid-base equilibria in homogeneous and heterogeneous systems of two antihistaminics, loratadine and desloratadine were studied spectrophotometrically in Britton-Robinson's buffer at 25 degrees C. Acidity constant of loratadine was found to be pK(a) 5.25 and those of desloratadine pK(a1) 4.41 and pK(a2) 9.97. The values of intrinsic solubilities of loratadine and desloratadine were 8.65x10(-6) M and 3.82x10(-4) M, respectively. Based on the pK(a) values and intrinsic solubilities, solubility curves of these two drugs as a function of pH were calculated. The effects of anionic, cationic and non-ionic surfactants applied in the concentration exceeding critical micelle concentration (cmc) on acid-base properties of loratadine and desloratadine, as well as on intrinsic solubility of loratadine were also examined. The results revealed a shift of pK(a) values in micellar media comparing to the values obtained in water. These shifts (DeltapK(a)) ranged from -2.24 to +1.24. |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 1% |
| Unknown | 84 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 12% |
| Other | 9 | 11% |
| Student > Master | 9 | 11% |
| Researcher | 8 | 9% |
| Student > Ph. D. Student | 7 | 8% |
| Other | 20 | 24% |
| Unknown | 22 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 30 | 35% |
| Chemistry | 15 | 18% |
| Medicine and Dentistry | 8 | 9% |
| Chemical Engineering | 3 | 4% |
| Agricultural and Biological Sciences | 2 | 2% |
| Other | 3 | 4% |
| Unknown | 24 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2014.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Journal of Pharmaceutical & Biomedical Analysis
#908
of 4,794 outputs
Outputs of similar age
#37,084
of 102,623 outputs
Outputs of similar age from Journal of Pharmaceutical & Biomedical Analysis
#11
of 27 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,794 research outputs from this source. They receive a mean Attention Score of 2.8. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,623 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.