In cystic fibrosis (CF) there is early destruction of the exocrine pancreas and this results in a unique form of diabetes that affects approximately half of adult CF individuals. An animal model of cystic fibrosis-related diabetes has been developed in the ferret which progresses through phases of glycemic abnormalities due to islet remodeling during and after exocrine destruction. Here, we quantified the pancreatic histopathologic changes that occur during these phases. There was an increase in percent ductal, fat, and islet area in CF ferrets over time compared to age-matched WT controls. We also quantified islet size, shape, islet cell composition, cell proliferation (Ki67), and expression of remodeling markers (MMP7, desmin, and SMA). Pancreatic ducts were dilated with scattered proliferating cells and were surrounded by activated stellate cells, indicative of tissue remodeling. The timing of islet and duct proliferation, stellate cell activation, and matrix remodeling coincided with the previously published stages of glycemic crisis and inflammation. This mapping of remodeling events in the CF ferret pancreas provides insights into early changes that control glycemic intolerance and subsequent recovery during the evolution of CF pancreatic disease.
Pharmacology, Toxicology and Pharmaceutical Science
1
5%
Nursing and Health Professions
1
5%
Other
1
5%
Unknown
6
27%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2018.
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#22,960,233
of 34,376,207 outputs
Outputs from American Journal of Pathology
#7,621
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#307,453
of 492,301 outputs
Outputs of similar age from American Journal of Pathology
#27
of 43 outputs
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