PET and SPECT ligands for the norepinephrine transporter (NET) will be important tools for studying the physiology, pathophysiology and pharmacology of the CNS noradrenergic system in vivo. A series of candidate NET ligands were synthesized and characterized in terms of their affinity for human monoamine transporters. The two most promising compounds, talopram and talsupram, were radiolabeled with carbon-11 and evaluated through biodistribution studies in rats and PET imaging studies in a rhesus monkey. Although both compounds displayed high affinity and selectivity for the human NET in vitro, these compounds did not enter the CNS in adequate amounts to be used in PET imaging studies.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2020.
All research outputs
#12,343,970
of 34,359,530 outputs
Outputs from Nuclear Medicine & Biology
#824
of 1,753 outputs
Outputs of similar age
#37,725
of 87,623 outputs
Outputs of similar age from Nuclear Medicine & Biology
#5
of 19 outputs
Altmetric has tracked 34,359,530 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,753 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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