Campylobacter jejuni
is a leading cause of bacterial-derived gastroenteritis worldwide.Campylobacteris most commonly acquired through the consumption of undercooked poultry meat or through drinking contaminated water. Following ingestion,Campylobacteradheres to the intestinal epithelium and mucus layer, causing toxin-mediated inflammation and inhibition of fluid reabsorption. Currently, the human response to infection is relatively unknown and animal hosts that model those responses are rare. As such, we examined patient fecal samples for the accumulation of the neutrophil protein, calgranulin C, during infection withCampylobacter jejuni.In response to infection, calgranulin C was significantly increased in the feces of humans. To determine whether calgranulin C accumulation occurs in an animal model, we examined for disease in ferrets. Ferrets were effectively infected byC. jejuniwith peak fecal loads observed at day three post-infection and full resolution by day 12. Serum levels of IL-10 and TNFa significantly increased in response to infection, which resulted in leukocyte trafficking to the colon. As a result, calgranulin C increased in the feces of ferrets at the time whenC. jejuniloads decreased. Further, the addition of purified calgranulin C toC. jejunicultures was found to inhibit growth in a zinc-dependent manner. These results suggest that upon infection withC. jejuni, leukocytes trafficked to the intestine release calgranulin C as a mechanism for inhibitingC. jejunigrowth.
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2018.
All research outputs
#16,053,755
of 25,382,440 outputs
Outputs from Infection and Immunity
#11,455
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Outputs of similar age
#198,644
of 343,949 outputs
Outputs of similar age from Infection and Immunity
#32
of 70 outputs
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