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The Importance of Body Composition in Explaining the Overweight Paradox in Cancer—Counterpoint

Overview of attention for article published in Cancer Research, April 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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5 X users
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1 Facebook page
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1 YouTube creator

Citations

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138 Dimensions

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108 Mendeley
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Title
The Importance of Body Composition in Explaining the Overweight Paradox in Cancer—Counterpoint
Published in
Cancer Research, April 2018
DOI 10.1158/0008-5472.can-17-3287
Pubmed ID
Authors

Bette J Caan, Elizabeth M Cespedes Feliciano, Candyce H Kroenke

Abstract

Despite a greater risk of cancer associated with higher BMI, overweight (BMI 25-<30 kg/m2) and class I obese (BMI 30-<35 kg/m2) patients often have a paradoxically lower risk of overall mortality after a cancer diagnosis, a phenomenon called the "obesity paradox." Only when patients exceed a BMI ≥35 kg/m2 are elevations in mortality risk consistently noted. This paradox has been dismissed as the result of methodologic bias, which we will describe and debate here. However, even if such bias influences associations, there is growing evidence that body composition may in part explain the paradox. This phenomenon may more accurately be described as a BMI paradox. That is, BMI is a poor proxy for adiposity and does not distinguish muscle from adipose tissue, nor describe adipose tissue distribution. Low muscle mass is associated with higher risk of recurrence, overall and cancer-specific mortality, surgical complications, and treatment-related toxicities. Patients with who are overweight or obese have on average higher levels of muscle than their normal-weight counterparts. Also, there is some evidence that patients with moderate levels of subcutaneous adipose tissue may have lower mortality. More research utilizing body composition is needed to clarify the effects of adiposity on cancer mortality. Cancer Res; 78(8); 1906-12. ©2018 AACR.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 108 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 12%
Researcher 12 11%
Student > Master 11 10%
Student > Bachelor 9 8%
Other 9 8%
Other 12 11%
Unknown 42 39%
Readers by discipline Count As %
Medicine and Dentistry 33 31%
Nursing and Health Professions 8 7%
Biochemistry, Genetics and Molecular Biology 3 3%
Engineering 3 3%
Sports and Recreations 2 2%
Other 9 8%
Unknown 50 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2024.
All research outputs
#7,890,770
of 25,253,876 outputs
Outputs from Cancer Research
#7,922
of 19,137 outputs
Outputs of similar age
#126,187
of 335,344 outputs
Outputs of similar age from Cancer Research
#58
of 151 outputs
Altmetric has tracked 25,253,876 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 19,137 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,344 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 151 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.