Social cognitive difficulties are common in the acute phase of bipolar disorder and to a lesser extent during the euthymic stage, and imaging studies of social cognition in euthymic bipolar disorder have implicated mirror system brain regions. This study aimed to use a novel multimodal approach (i.e. including both TMS and EEG) to investigate mirror systems in bipolar disorder. 15 individuals with euthymic bipolar disorder and 16 healthy controls participated in this study. Single-pulse TMS was applied to the optimal site in the primary motor cortex (M1) which stimulates the muscle of interest during the observation of hand movements (goal-directed or interacting) designed to elicit mirror system activity. Single EEG electrodes (C3, CZ, C4) recorded mu rhythm modulation concurrently. Results revealed that the patient group showed significantly less mu suppression compared to healthy controls. Surprisingly, motor resonance was not significantly different overall between groups, however, bipolar disorder participants showed a pattern of reduced reactivity on some conditions. While preliminary, this study indicates a potential mirror system deficit in euthymic bipolar disorder which may contribute to the pathophysiology of the disorder.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2015.
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#12,936,348
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#319
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#118,225
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Outputs of similar age from Social Neuroscience
#11
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Altmetric has tracked 23,325,355 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 578 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.2. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
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