The effects of the persistent peroxisome proliferator, perfluorodecanoic acid (PFDA), on growth, feed intake and the enzyme activities associated with peroxisomal beta-oxidation were studied in female Sprague Dawley rats. Rats received one of six levels of PFDA (0, 0.3, 1.0, 3.0, 10.0 or 30.0 mg/kg/injection) in four IP doses at 2-week intervals. Rats with cumulative doses of less than or equal to 12.0 mg/kg did not differ from control rats in growth or feed intake, while rats receiving cumulative doses of greater than or equal to mg/kg lost weight and decreased their feed intake. Rats which received cumulative doses between these levels increased their feed intake but did not significantly alter their body weight. Total peroxisomal beta-oxidation was decreased in a dose-related manner, whereas the liver to body weight ratio and the activities of individual enzymes comprising the peroxisomal beta-oxidation system, namely fatty acyl-CoA oxidase, enoyl-CoA hydratase, 3-hydroxy-acyl-CoA dehydrogenase, and thiolase, were increased. This study clearly shows that the inhibition of peroxisomal beta-oxidation by PFDA is not reflected in the in vitro measurement of the individual enzyme activities comprising this pathway.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2009.
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#8,899,175
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#894
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Outputs of similar age from Archives of Toxicology
#7
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