Title |
The catecholamine system in health and disease
|
---|---|
Published in |
Proceedings of the Japan Academy, Series B: Physical and Biological Sciences, January 2007
|
DOI | 10.2183/pjab.82.388 |
Pubmed ID | |
Authors |
Toshiharu Nagatsu |
Abstract |
Catecholamines [dopamine, noradrenaline (norepinephrine), and adrenaline (epinephrine); CAs] are neurotransmitters in the central and peripheral nervous systems as well as hormones in the endocrine system. CAs in the brain play a central role in versatile functions as slow-acting neurotransmitters functioning in synaptic neurotransmission, modulating the effects of fast-acting neurotransmitters such as glutamate and γ-aminobutyric acid (GABA). In this review, I focus on recent advances in the biochemistry and molecular biology of the CA system in humans in health and disease, especially in neuropsychiatric diseases such as Parkinson's disease (PD), in relation to the biosynthesis of CAs regulated by a pteridine-dependent monooxygenase, tyrosine 3-monooxygenase (tyrosine hydroxylase, TH) and its pteridine cofactor, tetrahydrobiopterin (BH4). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 91 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 17 | 19% |
Student > Ph. D. Student | 15 | 16% |
Student > Master | 10 | 11% |
Unspecified | 6 | 7% |
Researcher | 5 | 5% |
Other | 11 | 12% |
Unknown | 27 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 19% |
Agricultural and Biological Sciences | 10 | 11% |
Unspecified | 6 | 7% |
Medicine and Dentistry | 6 | 7% |
Neuroscience | 5 | 5% |
Other | 19 | 21% |
Unknown | 28 | 31% |