Title |
Parametric versus non-parametric statistics in the analysis of randomized trials with non-normally distributed data
|
---|---|
Published in |
BMC Medical Research Methodology, November 2005
|
DOI | 10.1186/1471-2288-5-35 |
Pubmed ID | |
Authors |
Andrew J Vickers |
Abstract |
It has generally been argued that parametric statistics should not be applied to data with non-normal distributions. Empirical research has demonstrated that Mann-Whitney generally has greater power than the t-test unless data are sampled from the normal. In the case of randomized trials, we are typically interested in how an endpoint, such as blood pressure or pain, changes following treatment. Such trials should be analyzed using ANCOVA, rather than t-test. The objectives of this study were: a) to compare the relative power of Mann-Whitney and ANCOVA; b) to determine whether ANCOVA provides an unbiased estimate for the difference between groups; c) to investigate the distribution of change scores between repeat assessments of a non-normally distributed variable. |
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