Title |
Inhalation Anesthesia Is Preferable for Recording Rat Cardiac Function Using an Electrocardiogram
|
---|---|
Published in |
Biological and Pharmaceutical Bulletin, January 2014
|
DOI | 10.1248/bpb.b14-00012 |
Pubmed ID | |
Authors |
Manabu Murakami, Hidetoshi Niwa, Tetsuya Kushikata, Hiroyuki Watanabe, Kazuyoshi Hirota, Kyoichi Ono, Takayoshi Ohba |
Abstract |
The effects of inhalation anesthesia (2% isoflurane, sevoflurane, or enflurane) and intraperitoneal anesthesia with pentobarbital (65 mg/kg) were compared in rats using an electrocardiogram (ECG) and determination of blood oxygen saturation (SPO2) levels. Following inhalation anesthesia, heart rate (HR) and SPO2 were acceptable while pentobarbital anesthesia decreased HR and SPO2 significantly. This indicates that inhalation anesthesia is more preferable than pentobarbital anesthesia when evaluating cardiovascular factors. Additionally, pentobarbital significantly increased HR variability (HRV), suggesting a regulatory effect of pentobarbital on the autonomic nervous system, and resulted in a decreased response of the baro-reflex system. Propranolol or atropine had limited effects on ECG recording following pentobarbital anesthesia. Taken together, these data suggest that inhalation anesthesia is suitable for conducting hemodynamic analyses in the rat. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Peru | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 17% |
Student > Master | 6 | 15% |
Student > Bachelor | 5 | 12% |
Professor > Associate Professor | 5 | 12% |
Student > Ph. D. Student | 4 | 10% |
Other | 7 | 17% |
Unknown | 7 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 32% |
Agricultural and Biological Sciences | 8 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 12% |
Engineering | 2 | 5% |
Sports and Recreations | 1 | 2% |
Other | 3 | 7% |
Unknown | 9 | 22% |