IRF7: activation, regulation, modification and function

Overview of attention for article published in Genes & Immunity, April 2011

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In the top 5% of all research outputs scored by Altmetric
Among the highest-scoring outputs from this source (#12 of 1,015)
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Type I interferons have downstream effects that can suppress tumors, notably through other related genes and pathways. These processes have an impact on controlling cancer development, including breast, prostate, uterus, ovaries, and pancreatic cancers.…

“IRF7 is predominantly activated by TLR7 in pDCs, in which both TLR7 and IRF7 are expressed at extra high levels that make these cells ‘professional’ producers of type I IFNs.” https://t.co/DvB4P7rnsH https://t.co/tyV7OlVL5i

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