Iron homeostasis is disrupted in multiple myeloma (MM), a difficult-to-cure plasma cell malignancy with lytic bone lesions. Here we systematically analyzed iron gene expression signature and demonstrated that mRNA expression of iron exporter Ferroportin (FPN1) is significantly downregulated in myeloma cells and correlates negatively with clinic outcome. Restoring expression of FPN1 reduces intracellular liable iron pool, inhibits STAT3-MCL-1 signaling and suppresses myeloma cells growth. Furthermore, we demonstrated that mRNA of FPN1 is also downregulated at the initial stages of osteoclast differentiation and suppresses myeloma cell induced osteoclast differentiation through regulating iron regulator TFRC, NFκB and JNK pathways. Altogether, we demonstrated that downregulation of FPN1 plays critical roles in promoting myeloma cell growth and bone resorption in MM.
Pharmacology, Toxicology and Pharmaceutical Science
2
5%
Medicine and Dentistry
2
5%
Nursing and Health Professions
1
2%
Other
2
5%
Unknown
21
49%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2022.
All research outputs
#6,759,185
of 34,350,842 outputs
Outputs from Cancer Research
#10,564
of 35,807 outputs
Outputs of similar age
#65,518
of 309,489 outputs
Outputs of similar age from Cancer Research
#49
of 164 outputs
Altmetric has tracked 34,350,842 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 35,807 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,489 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 164 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
