Individuals with elevated lipid levels are at risk for developing cardiovascular disease as well as cancer. Sterol regulatory element-binding protein transcription factors (SREBPs) are inducers of lipid synthesis. Elevated SREBPs levels are linked to cell proliferation and metastasis. Using biochemical and mouse models of cancer, Zhao et al. have discovered that nuclear SREBP-1a-dependent transcription is activated by pyruvate kinase M2 in cancer cells, which promotes tumor growth. Targeting the lipogenesis pathway may therefore be a promising avenue for cancer treatment.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2018.
All research outputs
#9,083,441
of 26,746,546 outputs
Outputs from Journal of Biological Chemistry
#34,273
of 87,030 outputs
Outputs of similar age
#141,769
of 348,359 outputs
Outputs of similar age from Journal of Biological Chemistry
#199
of 402 outputs
Altmetric has tracked 26,746,546 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 87,030 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,359 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 402 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
