| Title |
BAD Phosphorylation Determines Ovarian Cancer Chemosensitivity and Patient Survival
|
|---|---|
| Published in |
Clinical Cancer Research, October 2011
|
| DOI | 10.1158/1078-0432.ccr-11-0735 |
| Pubmed ID | |
| Authors |
Douglas C. Marchion, Hope M. Cottrill, Yin Xiong, Ning Chen, Elona Bicaku, William J. Fulp, Nisha Bansal, Hye Sook Chon, Xiaomang B. Stickles, Siddharth G. Kamath, Ardeshir Hakam, Lihua Li, Dan Su, Carolina Moreno, Patricia L. Judson, Andrew Berchuck, Robert M. Wenham, Sachin M. Apte, Jesus Gonzalez-Bosquet, Gregory C. Bloom, Steven A. Eschrich, Said Sebti, Dung-Tsa Chen, Johnathan M. Lancaster |
| Abstract |
Despite initial sensitivity to chemotherapy, ovarian cancers (OVCA) often develop drug resistance, which limits patient survival. Using specimens and/or genomic data from 289 patients and a panel of cancer cell lines, we explored genome-wide expression changes that underlie the evolution of OVCA chemoresistance and characterized the BCL2 antagonist of cell death (BAD) apoptosis pathway as a determinant of chemosensitivity and patient survival. |
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Mendeley demographics
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