Title |
HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells
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Published in |
Retrovirology, May 2015
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DOI | 10.1186/s12977-015-0160-x |
Pubmed ID | |
Authors |
Maria Pino, Itziar Erkizia, Susana Benet, Elina Erikson, Maria Teresa Fernández-Figueras, Dolores Guerrero, Judith Dalmau, Dan Ouchi, Antonio Rausell, Angela Ciuffi, Oliver T Keppler, Amalio Telenti, Hans-Georg Kräusslich, Javier Martinez-Picado, Nuria Izquierdo-Useros |
Abstract |
Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. The receptor Siglec-1 (CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout the course of HIV-1 infection, such as interferon α (IFNα). Here we show that IFNα-activated dendritic cells, monocytes and macrophages have an enhanced ability to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides. Monocytes from untreated HIV-1-infected individuals trans-infect HIV-1 via Siglec-1, but this capacity diminishes after effective antiretroviral treatment. Furthermore, Siglec-1 is expressed on myeloid cells residing in lymphoid tissues, where it can mediate viral trans-infection. Siglec-1 on myeloid cells could fuel novel CD4(+) T-cell infections and contribute to HIV-1 dissemination in vivo. |
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Geographical breakdown
Country | Count | As % |
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United States | 4 | 29% |
Spain | 1 | 7% |
Venezuela, Bolivarian Republic of | 1 | 7% |
United Kingdom | 1 | 7% |
Unknown | 7 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 12 | 86% |
Science communicators (journalists, bloggers, editors) | 2 | 14% |
Mendeley readers
Geographical breakdown
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Netherlands | 1 | 1% |
France | 1 | 1% |
Unknown | 94 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 21 | 22% |
Researcher | 13 | 14% |
Student > Master | 13 | 14% |
Student > Bachelor | 10 | 10% |
Professor > Associate Professor | 4 | 4% |
Other | 10 | 10% |
Unknown | 25 | 26% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 21 | 22% |
Immunology and Microbiology | 21 | 22% |
Biochemistry, Genetics and Molecular Biology | 13 | 14% |
Medicine and Dentistry | 11 | 11% |
Engineering | 2 | 2% |
Other | 2 | 2% |
Unknown | 26 | 27% |