Existing regulatory frameworks for aquatic pollutants in the United States are idealized, often lacking mechanisms to account for contaminants characterized by (1) bioactivity of both the parent and transformation products and (2) reversible transformations (that is, metastable products) driven by chemical or physical heterogeneities. Here, we modelled a newly discovered product-to-parent reversion pathway for trenbolone acetate (TBA) metabolites. We show increased exposure to the primary metabolite, 17α-trenbolone (17α-TBOH), and elevated concentrations of the still-bioactive primary photoproduct hydroxylated 17α-TBOH, produced via phototransformation and then converted back to 17α-trenbolone in perpetually dark hyporheic zones that exchange continuously with surface water photic zones. The increased persistence equates to a greater potential hazard from parent-product joint bioactivity at locations and times when reversion is a dominant trenbolone fate pathway. Our study highlights uncertainties and vulnerabilities with current paradigms in risk characterization.
This research output has an Altmetric Attention Score of 70. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2016.
All research outputs
#737,594
of 31,836,582 outputs
Outputs from Nature Communications
#12,927
of 76,871 outputs
Outputs of similar age
#7,100
of 295,473 outputs
Outputs of similar age from Nature Communications
#89
of 764 outputs
Altmetric has tracked 31,836,582 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 76,871 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.3. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,473 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 764 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.
