| Title |
The vaginal and gastrointestinal microbiomes in gynecologic cancers: A review of applications in etiology, symptoms and treatment
|
|---|---|
| Published in |
Gynecologic Oncology, May 2015
|
| DOI | 10.1016/j.ygyno.2015.04.036 |
| Pubmed ID | |
| Authors | |
| Abstract |
The human microbiome is the collection of microorganisms in the body that exist in a mutualistic relationship with the host. Recent studies indicate that perturbations in the microbiome may be implicated in a number of diseases, including cancer. More specifically, changes in the gut and vaginal microbiomes may be associated with a variety of gynecologic cancers, including cervical cancer, uterine cancer, and ovarian cancer. Current research and gaps in knowledge regarding the association between the gut and vaginal microbiome and the development, progression, and treatment of gynecologic cancers is reviewed here. In addition, the potential use of probiotics to manage symptoms of these gynecologic cancers is discussed. A better understanding of how the microbiome composition is altered at these sites and its interaction with the host may aid in prevention, optimization of current therapies, development of new therapeutic agents and/or dosing regimens, and possibly limit the side effects associated with cancer treatment. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Italy | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Unknown | 247 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 39 | 16% |
| Student > Bachelor | 30 | 12% |
| Student > Master | 25 | 10% |
| Student > Ph. D. Student | 21 | 8% |
| Other | 17 | 7% |
| Other | 45 | 18% |
| Unknown | 73 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 52 | 21% |
| Biochemistry, Genetics and Molecular Biology | 36 | 14% |
| Agricultural and Biological Sciences | 26 | 10% |
| Immunology and Microbiology | 12 | 5% |
| Nursing and Health Professions | 11 | 4% |
| Other | 22 | 9% |
| Unknown | 91 | 36% |