Noelle C. Bowdler, Debbie S. Beasley, E.Cristina Fritze, Ann M. Goulette, James D. Hatton, James Hession, David L. Ostman, David J. Rugg, Charles J. Schmittdiel
Abstract
Abnormally high brain aluminum concentrations have been detected in hemodialysis patients who died of an unexplained encephalopathy. As a result, this study was undertaken to examine whether the ingestion of aluminum produces behavioral aberrations in non-dialysed human subjects and rats with ostensibly normal renal function. Rats were fed AlCl3 by intubation in varying doses, and tests measuring learning ability, visual temporal acuity, motor coordination and activity were administered. It was found that orally ingested aluminum is absorbed by rats and deposited in the brain. High brain aluminum levels are associated with rapid general activity, decreased ability to maintain roto-rod activity, and increased sensitivity to flicker. Behavioral tests were also given to elderly human subjects and performance correlated with serum aluminum level. High serum levels of aluminum in elderly humans are associated with impaired visuo-motor coordination, poor long-term memory, and increased sensitivity to flicker.
Pharmacology, Toxicology and Pharmaceutical Science
1
6%
Biochemistry, Genetics and Molecular Biology
1
6%
Business, Management and Accounting
1
6%
Other
4
24%
Unknown
4
24%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2024.
All research outputs
#23,088,086
of 34,517,649 outputs
Outputs from Pharmacology, Biochemistry & Behavior
#3,243
of 4,277 outputs
Outputs of similar age
#7,998
of 8,766 outputs
Outputs of similar age from Pharmacology, Biochemistry & Behavior
#14
of 17 outputs
Altmetric has tracked 34,517,649 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,277 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 8,766 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
