Maternal nutritional deficiency significantly perturbs the offspring's physiology predisposing them to metabolic diseases during adulthood. Vitamin B12 and folate are two such micronutrients, whose deficiency leads to elevated homocysteine levels. We earlier generated B12 and/or folate deficient rat models and using high-throughput proteomic approach, showed that maternal vitamin B12 deficiency modulates carbohydrate and lipid metabolism in the liver of pups through regulation of PPAR signalling pathway. In this study, using similar approach, we identified 26 differentially expressed proteins in the kidney of pups born to mothers fed with vitamin B12 deficient diet while only four proteins were identified in the folate deficient group. Importantly, proteins like calreticulin, cofilin 1 and nucleoside diphosphate kinase B that are involved in the functioning of the kidney were upregulated in B12 deficient group. Our results hint towards a larger effect of vitamin B12 deficiency compared to that of folate presumably due to greater elevation of homocysteine in vitamin B12 deficient group. In view of widespread vitamin B12 and folate deficiency and its association with several diseases like Anaemia, cardiovascular and renal diseases, our results may have large implications for kidney diseases in populations deficient in vitamin B12 especially in vegetarians and the elderly people.
Since Vitamin B12 and folate deficiency has been shown to be an enormous public health problem and is related to several diseases like Anaemia, cardiovascular disease and renal disease; it is important to identify the different perturbed pathways in specific tissue of interest. Here using a rat model we have been able to probe tissue based proteomic alteration in these micronutrient deficiency group. Our study may have large implications in populations deficient in vitamin B12 especially in vegeterians and elderly populations.
Pharmacology, Toxicology and Pharmaceutical Science
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3%
Other
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Unknown
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Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2015.
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#16,720,137
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Outputs from Journal of Proteomics
#1,857
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Outputs of similar age
#159,049
of 278,944 outputs
Outputs of similar age from Journal of Proteomics
#30
of 73 outputs
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