Title |
Anti-Ebola Activity of Diazachrysene Small Molecules
|
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Published in |
ACS Infectious Diseases, May 2015
|
DOI | 10.1021/acsinfecdis.5b00028 |
Pubmed ID | |
Authors |
Života Selaković, Veronica Soloveva, Dima N. Gharaibeh, Jay Wells, Sandra Šegan, Rekha G. Panchal, Bogdan A. Šolaja |
Abstract |
Herein we report on a diazachrysene class of small molecules that exhibit potent antiviral activity against the Ebola (EBOV) virus. The antiviral compounds are easily synthesized, and the most active compounds have excellent in vitro activity (0.34-0.70 μM) and are significantly less lipophilic than their predecessors. The three most potent diazachrysene antivirals do not exhibit any toxicity in vivo and protected 70-90% of the mice at 10 mg/kg following EBOV challenge. Together, these studies suggest that diazachrysenes are a promising class of compounds for hit to lead optimization and as potential Ebola therapeutics. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 24% |
Student > Bachelor | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Student > Master | 3 | 12% |
Other | 2 | 8% |
Other | 3 | 12% |
Unknown | 5 | 20% |
Readers by discipline | Count | As % |
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Chemistry | 11 | 44% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Medicine and Dentistry | 3 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 20% |