The UPICT FDG PET-CT Protocol is intended to guide the performance of whole-body FDG-PET/CT studies within the context of single- and multi-center clinical trials of oncologic therapies by providing acceptable (minimum), target, and ideal standards for all phases of the imaging. The aim is to minimize intra- and inter-subject, intra- and inter-platform, inter-examination, and inter-institutional variability of primary and/or derived data. The goal of this condensed version of the much larger document is to make readers aware of the general content and subject area. The full document is available on line. The main subjects areas in the document are: Context of the imaging protocol within the clinical trial, Site selection, Qualification and training, Subject scheduling, Subject preparation, Imaging related substance preparation and administration, Imaging procedure, Image post-processing, Image analysis, Image interpretation, Archival and distribution of data, Quality control, and Imaging-associated risks and risk management.