Tumor associated macrophages (TAM) play a critical role in cancer development and progression. However, the heterogeneity of TAM presents a major challenge to identify clinically-relevant markers for pro-tumor TAM. Here, we report that expression of adipocyte/macrophage fatty acid binding protein (A-FABP) in TAM promotes breast cancer progression. While upregulation of A-FABP was inversely associated with breast cancer survival, deficiency of A-FABP significantly reduced mammary tumor growth and metastasis. Furthermore, the pro-tumor effect of A-FABP was mediated by TAM, in particular in a subset of TAM with a CD11b+F4/80+MHCII-Ly6C- phenotype. A-FABP expression in TAM facilitated pro-tumor IL-6/STAT3 signaling through regulation of NFκB/miR-29b pathway. Collectively, our results suggest A-FABP as a new functional marker for pro-tumor TAM.
Pharmacology, Toxicology and Pharmaceutical Science
5
4%
Agricultural and Biological Sciences
4
3%
Other
10
9%
Unknown
47
41%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2023.
All research outputs
#12,327,560
of 34,350,842 outputs
Outputs from Cancer Research
#19,164
of 35,807 outputs
Outputs of similar age
#154,923
of 370,013 outputs
Outputs of similar age from Cancer Research
#84
of 161 outputs
Altmetric has tracked 34,350,842 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
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