Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Overview of attention for article published in Nature Genetics, October 2011

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Locus 22q11.23 containing GGT* genes is one of the strongest associated GWAS loci for serum GGT. https://t.co/rGUpse6Np3 https://t.co/9aiKrAtY4q

At the PNPLA3 locus, the index variant (rs738409) is a missense variant and its association with liver disease is well characterised. It is one of the four locus identified in an earlier GWAS of ALT in only 45k individuals (1/10th of current sample size…

RT @skathire: @joe_pickrell @NouraAbulHusn @RickDewey @regeneron @GeisingerRsrch In 2011, Chambers performed GWAS for ALT level and found r…

@joe_pickrell @NouraAbulHusn @RickDewey @regeneron @GeisingerRsrch In 2011, Chambers performed GWAS for ALT level and found rs6834314 (MAF 25%) downstream of HSD17B13 to be associated with ALT. But not able to definitively localize to HSD17B13 as causal …

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