Periodontitis is correlated with type 2 diabetes mellitus (T2DM), but little is known about glycemic status effect on subgingival microbiota associated with periodontitis. This study evaluated if periodontal microbiome of T2DM patients is affected by glycemic status.
21 T2DM non-smoking patients with chronic periodontitis and body mass index ≤40kg/m2 were allocated into two groups according to systemic glycemic status: inadequate (DMI- HbA1c≥8%) and adequate (DMA- HbA1c<7.8%). Subgingival biofilm was collected from sites with moderate (PD=4-6mm) and severe disease (PD≥7mm) in two quadrants. The V5-V6 hypervariable region of the 16SrRNA was sequenced using the GS-FLX-454Titanium platform. Sequences were compared to HOMD database using QIIME and PhyloToAST pipelines. Statistical comparisons were made using 2-sample t-tests.
DMA microbiome presented higher diversity than DMI. Inadequate glycemic control favored fermenting species, especially those associated with propionate/succinate production, whereas those forming butyrate/pyruvate were decreased in DMI. Higher abundances of anginosus group and Streptococcus agalactiae in DMI may indicate that subgingival sites can be reservoir of potentially invasive pathogens. Altered subgingival microbiome in DMI may represent an additional challenge in the periodontal treatment of these patients and in the prevention of more invasive infections.
Glycemic status in T2DM patients seems to modulate subgingival biofilm composition. This article is protected by copyright. All rights reserved.
Pharmacology, Toxicology and Pharmaceutical Science
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2%
Nursing and Health Professions
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2%
Other
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Unknown
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41%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2025.
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#3,780,921
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Outputs from Journal of Clinical Periodontology
#271
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#57,867
of 360,281 outputs
Outputs of similar age from Journal of Clinical Periodontology
#9
of 36 outputs
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.
