Mice lacking glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) are unable to traffic LPL to the vascular lumen. Thus, TG clearance is severely blunted, and mice are extremely hypertriglyceridemic. Paradoxically, mice lacking both GPIHBP1 and the LPL regulator angiopoietin-like 4 (ANGPTL4) are far less hypertriglyceridemic. We sought to determine the mechanism by which Angptl4-/-Gpihbp1-/- double knockout mice clear plasma triglycerides. We confirmed that, on a normal chow diet, plasma TG levels were lower in Angptl4-/-Gpihbp1-/- mice than in Gpihbp1-/- mice; however, the difference disappeared with administration of a high-fat diet. Although LPL remained mislocalized in double-knockout mice, plasma TG clearance in brown adipose tissue increased compared with Gpihbp1-/- mice. Whole lipoprotein uptake was observed in the brown adipose tissue of both Gpihbp1-/- and Angptl4-/-Gpihbp1-/- mice, but brown adipose tissue lipase activity was significantly higher in the double-knockout mice. We conclude that Angptl4-/-Gpihbp1-/- mice clear plasma TGs primarily through a slow and non-canonical pathway that includes the uptake of whole lipoprotein particles.
Pharmacology, Toxicology and Pharmaceutical Science
2
10%
Agricultural and Biological Sciences
2
10%
Arts and Humanities
1
5%
Biochemistry, Genetics and Molecular Biology
1
5%
Other
2
10%
Unknown
9
45%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2024.
All research outputs
#22,358,383
of 32,360,424 outputs
Outputs from Journal of Lipid Research
#4,909
of 5,721 outputs
Outputs of similar age
#235,797
of 360,901 outputs
Outputs of similar age from Journal of Lipid Research
#52
of 59 outputs
Altmetric has tracked 32,360,424 research outputs across all sources so far. This one is in the 29th percentile – i.e., 29% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,721 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,901 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
