To investigate the diagnostic value of tumor blood flow (TBF) obtained with pseudo-continuous arterial spin labeling (pCASL) for the differentiation of squamous cell carcinoma (SCC) and inverted papilloma (IP) in the nasal or sinonasal cavity.
We retrospectively analyzed the cases of 33 patients with SCC and eight patients with IP in the nasal or sinonasal cavity. pCASL scanning was performed for all patients using a 3T MR-unit. Quantitative TBF values were measured by two neuroradiologists by respectively delineating the whole-tumor region of interest (ROIs), and the mean of them was determined as TBF value in each patient. Additionally, the presence of imaging findings of convoluted cerebriform pattern (CCP) on MR-T2WI was determined in all patients. As a subgroup analysis, patients with IP were divided into aggressive and non-aggressive IPs depending on their progression range. First, an intraclass correlation coefficient (ICC) of TBF values between two neuroradiologists was determined. Next, a statistical comparison of the TBF value by a Mann-Whitney U-test between the SCC and IP patients was performed. Additionally, the comparison by a one-way analysis of variance (ANOVA) with a post-hoc test of Tukey's method between the SCC, non-aggressive IP, and aggressive IP groups was also performed. If significance was observed, the diagnostic accuracy to differentiate SCCs from IPs was calculated. Diagnostic accuracy by CPP findings alone and by the combination of CPP findings and TBF were also assessed.
The ICC of TBF values between two neuroradiologists was 0.82. The mean TBF values in the patients with SCC, all patients with IP, those with aggressive IP, and those with non-aggressive IP were 141.2 ± 33.1, 77.8 ± 31.5, 109.4 ± 16.7, and 58.8 ± 19.9 mL/100g/min, respectively. A significant difference was observed between SCC and IP (p<0.001), SCC and non-aggressive IP (p<0.01), and non-aggressive IP and aggressive IP (p<0.01). The diagnostic accuracy values obtained with ROC curve analysis for the differentiation of SCC from IP and for SCC from non-aggressive IP were 0.90 and 0.92, respectively. The diagnostic accuracy was elevated (0.95 from 0.88) by adding the TBF value to CPP findings.
The pCASL technique can be a useful noninvasive diagnostic tool to differentiate SCC from IP in nasal or sinonasal cavity.
Pharmacology, Toxicology and Pharmaceutical Science
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5%
Biochemistry, Genetics and Molecular Biology
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Mathematics
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Engineering
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Other
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Unknown
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Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2015.
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#19,947,956
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Outputs from Dentomaxillofacial Radiology
#302
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#191,909
of 280,069 outputs
Outputs of similar age from Dentomaxillofacial Radiology
#7
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