| Title |
Changes in the mouse ovarian surface epithelium with age and ovulation number
|
|---|---|
| Published in |
Molecular & Cellular Endocrinology, May 2002
|
| DOI | 10.1016/s0303-7207(02)00061-8 |
| Pubmed ID | |
| Authors |
O.L. Clow, P.R. Hurst, J.S. Fleming |
| Abstract |
The cell biology of ovarian surface epithelium (OSE) was studied in mice of varying age and lifetime total ovulation number (OV#), to determine the relative importance of these factors in control of OSE proliferation and development of invaginations and cysts. Ovaries from Swiss Webster mice (total OV# median: range [n mice]) were collected at 4 weeks of age (prepubertal; 0[9]), from 3-month virgins (113: 11-235 [55]), from 12-month old breeders (217: 97-386 [21]) and from 8-month virgin mice, housed in split cages alongside a male, to induce continuous oestrous cycles (629: 456-908 [16]). Scanning electron microscopy revealed cuboidal and squamous cells in OSE from all ages. Higher total OV# markedly increased the rate of OSE invagination and layering. Histology showed the incidence of cysts, which had the appearance of benign serous cystadenomata, increased with age rather than total OV#. |
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Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 1 | 14% |
| Unknown | 6 | 86% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 29% |
| Student > Doctoral Student | 1 | 14% |
| Student > Bachelor | 1 | 14% |
| Professor | 1 | 14% |
| Student > Master | 1 | 14% |
| Other | 0 | 0% |
| Unknown | 1 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 43% |
| Biochemistry, Genetics and Molecular Biology | 2 | 29% |
| Medicine and Dentistry | 1 | 14% |
| Unknown | 1 | 14% |