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p53 Pathway in Renal Cell Carcinoma Is Repressed by a Dominant Mechanism

Overview of attention for article published in Cancer Research, March 2004
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

blogs
1 blog
patent
1 patent

Citations

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92 Dimensions

Readers on

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46 Mendeley
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Title
p53 Pathway in Renal Cell Carcinoma Is Repressed by a Dominant Mechanism
Published in
Cancer Research, March 2004
DOI 10.1158/0008-5472.can-03-1541
Pubmed ID
Authors

Katerina V. Gurova, Jason E. Hill, Olga V. Razorenova, Peter M. Chumakov, Andrei V. Gudkov

Abstract

Renal cell carcinoma (RCC) rarely acquires mutations in p53 tumor suppressor gene, suggesting that p53 signaling in this tumor type might be repressed by some other mechanism. In fact, all four RCC-derived cell lines we tested maintained wild-type p53 but were not capable of transactivating p53-responsive reporters and endogenous p53-responsive genes. p53 protein in RCC showed normal response to genotoxic stress, including accumulation, nuclear translocation, and activation of specific DNA binding. Functional and expression analysis of Mdm2, MdmX, and Arf showed lack of involvement of these p53 regulators in the observed defect of p53 function in RCC. However, activation of p53-mediated transactivation could be achieved by extremely high levels of p53 attained by lentivirus vector-driven transduction, suggesting the involvement of a dominant inhibitor in repression of p53-dependent transactivation in RCC. Consistently, p53 inactivation prevailed in the hybrids of RCC cells with the cells possessing fully functional p53. Remarkably, cells of normal kidney epithelium also caused partial p53 repression in cell fusion experiments, suggesting that RCC-specific p53 repression may be based on an unknown dominant mechanism also acting in normal kidney tissue.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Ukraine 1 2%
Canada 1 2%
Unknown 43 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 28%
Researcher 7 15%
Student > Master 6 13%
Student > Bachelor 4 9%
Professor 4 9%
Other 7 15%
Unknown 5 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 41%
Medicine and Dentistry 12 26%
Biochemistry, Genetics and Molecular Biology 8 17%
Social Sciences 2 4%
Nursing and Health Professions 1 2%
Other 1 2%
Unknown 3 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2022.
All research outputs
#3,820,750
of 23,230,825 outputs
Outputs from Cancer Research
#3,676
of 17,992 outputs
Outputs of similar age
#7,945
of 57,999 outputs
Outputs of similar age from Cancer Research
#42
of 200 outputs
Altmetric has tracked 23,230,825 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,992 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 57,999 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 200 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.