Family 3 G-protein-coupled receptors (GPCRs) comprise the metabotropic glutamate (mglu) receptors, GABA(B) receptors, Ca(2+)-sensing receptors and some taste and putative pheromone receptors. All are composed of two domains, an extracellular ligand-binding domain and a transmembrane heptahelical domain that activates G proteins. Here we propose a model for the function of family 3 GPCRs that takes into account their structure. This model fits with specific pharmacological features of some family 3 GPCRs, such as modulation by positive and negative allosteric regulators. The model also reveals differences between GABA(B) receptors and Group I mglu receptors: in the former there is "tight" functional coupling between the two domains of the receptor whereas the "loose" coupling in the latter gives these receptors specific features not shared by many other GPCRs.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2024.
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#9,515,738
of 27,782,313 outputs
Outputs from Trends in Pharmacological Sciences
#1,367
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#47,021
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Outputs of similar age from Trends in Pharmacological Sciences
#7
of 14 outputs
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