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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction
|
|---|---|
| Published in |
Future Medicinal Chemistry, May 2018
|
| DOI | 10.4155/fmc-2017-0239 |
| Pubmed ID | |
| Authors |
Catarina Garcia, Catarina Oliveira Silva, Carlos M Monteiro, Marisa Nicolai, Ana Viana, Joana M Andrade, Isabel Barasoain, Tijana Stankovic, Jos Quintana, Inmaculada Hernndez, Ignacio Gonzlez, Francisco Estvez, Ana M Daz-Lanza, Catarina P Reis, Carlos AM Afonso, Milica Pesic, Patrcia Rijo |
| Abstract |
6,7-dehydroroyleanone (DHR) is a cytotoxic abietane present in the essential oil of Plectranthus madagascariensis. Different extraction parameters were tested, and its extraction optimization was accomplished with a Clevenger apparatus-based hydrodistillation. After isolation, its effect on microtubules, P-glycoprotein and caspases was assessed on several cell lines and the compound was coupled with hybrid nanoparticles. The results show that DHR does not interfere with microtubule formation, but evades the resistance mechanisms of P-glycoprotein. Strong activation of caspases-3 and -9 indicates that DHR is able to induce apoptosis by triggering the intrinsic cell death pathway. Moreover, the assembly of DHR with hybrid nanoparticles was able to potentiate the effect of DHR in cancer cells. DHR seems to be a promising starting material with anticancer properties to further be explored. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 18% |
| Student > Master | 6 | 15% |
| Professor > Associate Professor | 4 | 10% |
| Student > Bachelor | 4 | 10% |
| Librarian | 3 | 8% |
| Other | 9 | 23% |
| Unknown | 7 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 30% |
| Biochemistry, Genetics and Molecular Biology | 5 | 13% |
| Chemistry | 5 | 13% |
| Agricultural and Biological Sciences | 3 | 8% |
| Unspecified | 1 | 3% |
| Other | 4 | 10% |
| Unknown | 10 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2019.
All research outputs
#22,767,715
of 25,382,440 outputs
Outputs from Future Medicinal Chemistry
#1,051
of 1,194 outputs
Outputs of similar age
#298,655
of 339,382 outputs
Outputs of similar age from Future Medicinal Chemistry
#20
of 24 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,194 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,382 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.